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Of note, in STEP 3 intensive behavioral treatment was also administered in both arms, and in STEP 4 all patients were initially assigned to semaglutide 2.4 mg but were randomized 2:1 to semaglutide 2.4 or placebo after 20 weeks 25

Due to the subtle clinical features common among the general population, it is challenging to differentiate CTE from other diseases without pathologic confirmation

These medications particularly benefit patients with a BMI of 30 or more, who face four to five times higher risk of heart disease, stroke, and diabetes 2